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Description
Malfunction of astrocyte-mediated GABAergic regulation is supported by findings in GABRB2 -knockout mice, which exhibit astrocytic atrophy, degeneration of parvalbumin-expressing cortical interneurons, neuroinflammation and oxidative stress, aligning with key pathological features of schizophrenia 302
In a meta-analysis of reports from 2000 to 2020 [156], the 10-year recurrence-free survival rate was 80% (95%CI 7089%) and the 10-year cumulative OS rate was 76% (95%CI 7082%)
doi: 10.1038/s41467-020-18939-y 70 TacconelliE.CarraraE.SavoldiA.HarbarthS.MendelsonM.MonnetD
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