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Funding This work was supported by NIH R01MH096263

We treat the root cause or causes of the symptoms instead of merely trying to make the symptoms go away

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Unresolved inflammation results in formation of vulnerable plaques characterized by enhanced macrophage apoptosis and defective efferocytosis of apoptotic cells resulting in necrotic cell death leading to increased smooth muscle cell death, decreased extracellular matrix production, and collagen degradation by macrophage proteases