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In db/db mice, previous studies found that AMPK activation could reduce ROS production and increase mitochondrial biogenesis and ETC activity to alleviate kidney damage in diabetic models[150, 151]

It also serves as a carrier for storing fatty acids

11 The presence or absence of heel spurs is not helpful in diagnosing plantar fasciitis

f., Celastrol, is a pentacyclic triterpenoid compound that inhibits ototoxicity by activating heat shock protein (HSP) 32/heme oxygenase-1 (HO-1) and NF-E2-related factor-2 (Nrf2, a crucial component of the cellular oxidative stress response) in HCs in neomycin-treated mice [178]

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