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doi: 10.1111/all.12856

60 Wang et al conducted a study demonstrating that Quercetin activates the cAMP/Epac pathway, leading to the inhibition of inflammatory cytokine release in mouse lung tissue, the blockage of neutrophil recruitment, and a reduction in pathological changes linked to lung injury

Continuous stimulation of the inflammatory response leads to multiple interactions among infiltrating immune cells, hepatic stellate cells (leading to fibrosis and cirrhosis), and portal myofibroblasts (leading to multiple bile duct stenosis) [218, 229, 230]

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On the other hand, hypoxia can promote HIF1-mediated transcription of lactate dehydrogenase (LDH) and SLC7A11, activate intracellular lactate accumulation and cystine uptake, and promote tumor resistance to ferroptosis through the lactate/GPX4 pathway [193]