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PubMed Scholar Tijssen MR, Cvejic A, Joshi A

Management strategies: Keep individual doses at 100 mcg or below Limit total daily GHRP-6 exposure to 300 mcg Prioritize the bedtime dose (cortisol is naturally lowest at night) Monitor for signs of cortisol excess: disrupted sleep, increased abdominal fat, mood changes Consider cycling 8 weeks on, 4 weeks off to prevent cumulative cortisol effects Prolactin elevation GHRP-6 can increase prolactin secretion, though the clinical significance varies by dose and individual sensitivity

Lactate measurements Lactate was measured in cell media using the Lactate-Glo Assay (Promega)

A major regulator of the rate of NADPH production by the PPP in response to oxidative stress is the allosteric activation of G6PDH