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Utilizing the FAERS database for analysis, we also discovered that certain drug combinations, particularly the pairing of VPA with TMP, LEV, or OLZ, markedly heightened the risk of HE

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Given the observed changes in the respiratory quotient and perceived exertion, further studies could also explore the underlying biochemical mechanisms responsible for these effects, such as the role of L-carnitine in mitochondrial function, fat oxidation, and glycogen preservation during prolonged exercise

Moreover, recent studies have explored the potential link between elevated TMAO levels and various cancers