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HNE has an aldehyde on carbon-1, an adjacent C=C carbon-carbon double bond between carbon-2 and carbon-3, and a hydroxyl group bound to carbon-4

Our patients biological age dropped by 7.63 years, whereas his chronological age went up by 1.32 years

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All patients included in our study were on treatment with TNFi

The authors sincerely thank Professor Graham Rook (University College London, United Kingdom) for discussions on his Old Friends Hypothesis and critical reading of the manuscript, and Professor Hanna Kmita (Adam Mickiewicz University, Poznan, Poland) for a critical reading of the manuscript and helpful suggestions for its improvement