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During mitosis, when a cell divides, aberrant chromosomes that have two centromeres, lack a centromere, or are in the shape of a ring have difficulty in separating, resulting in daughter cells with unequal or asymmetric distribution of the parental genetic material

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ROS stimulate apoptosis in airway epithelial cells, as well as production of cytokines and growth factors (such as TGF- [152]) which play an important role in myofibroblast differentiation and collagen deposition, resulting in pro-fibrotic events and further reduced antioxidant capacity (Fig

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