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Costs and causes of Oncology Drug Attrition with the example of insulin-like Growth Factor-1 receptor inhibitors
10.3389/fphar.2021.742562 31 ByunM.-W
LncRNA ASMTL-AS1, which is down-regulated in lung cancer cells, can stimulate ferroptosis in lung cancer cells by binding to U2AF2 and stabilizing spermidine/spermine N1-acetyltransferase 1 (SAT1) [169]
In addition, the product of the reaction, L2HG, is known as an oncometabolite inhibiting KG-dependent dioxygenases such as TET-type and Jmjc-type demethylases 13,14
N., Amaral-Machado, L., & Egito, E
