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Ferroptosis inducers have shown good application prospects in tumor therapy, and some anti-rheumatic drugs such as methotrexate and sulfasalazine have been shown to have ferroptosis modulating effects

When the aforementioned treatments are unavailable, systemic therapy becomes the primary choice [7], encompassing chemotherapy, targeted therapy, and immunotherapy [8]

However, there are conflicting data concerning cisplatin treatment and p53 status in glioma cell lines

Nevertheless, both GSH and Pro share L-glutamate as a common biosynthesis precursor (Moat et al., 2003) (Figure 1)

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