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In human URAT1/SLC22A12 (another OAT family member), the equivalent arginine, R477 URAT1 , has a direct role in substrate coordination, forming a hydrogen bond with the substrate urate

Best of all, none of the patients reported relevant side effects, either during or after the treatment

Separation was achieved with HILIC column (250 4.0 mm, 5 m, Fortis, UK) maintained at 40 C

Constipation affects up to 20% of adults worldwide and can significantly affect quality of life

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