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Importantly, these epigenetic alterations have been shown to persist beyond the period of active androgen exposure, even after partial normalisation of circulating hormone levels

In these cases, there may be particularities in the metabolism and elimination of its derivatives that could affect their condition

Mitochondrial dysfunction leads to a loss of energy production, fatty acid accumulation, excess reactive oxygen species(ROS) generation, membrane instability, and a shift to glucose metabolism [1,2]