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These effects result in edema, demyelination, and peripheral nerve necrosis, impairing nerve conduction

Acute glycolytic flux generates lactate that acidifies the microenvironment, proton loads inactivating sirtuin deacetylases to impair peroxisome proliferator-activated receptor gamma coactivator 1 alpha-mediated mitochondrial biogenesis [71] while activating calcium-independent phospholipase A 2 to liberate arachidonic acid [72]

Because the surface of a protein usually contains multiple exposed lysine residues, this non-site-specific labeling is highly efficient but may also lead to heterogeneity of labeled products, which in analytical chemistry is both a challenge and an opportunity for elucidating protein topology

[Valproate-associated hyperammonemic encephalopathy