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Interestingly, the growth of tumour xenografts formed by ABCB1/MDR1-overexpressed MDR uterine sarcoma and breast cancer cell lines, knocked down for MET with shRNA, was reduced compared to tumours formed by control shRNA transfected cells [33]

Creating various drug delivery channels is also an option, as is improving drug delivery, drug biodistribution, and pharmacokinetics

A Phase I/II multicenter study of single-agent foretinib as first-line therapy in patients with advanced hepatocellular carcinoma

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