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While efforts to develop nonpharmacologic strategies and pharmacological solutions for fibromyalgia have resulted in three FDA-approved medications, existing data and clinical experiences suggest modest success rates due to a lack of efficacy or side effects, leading to low patient compliance

Patient education: Advise patients on possible side effects, injection site care, and the lifestyle modifications that will support their treatment outcomes

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Although therapeutic options are available for chronic pain and depression, less than 50% of all patients treated for chronic pain report a clinically meaningful (i.e., 50%) pain relief with current analgesic treatments, and only about 5060% of patients with major depressive disorders achieved remission after an adequate course with conventional antidepressants