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Abdominal surgery

Both traditional chemotherapeutics and targeted therapeutics can halt cell proliferation and induce cell death in a majority of melanoma cells, but both can leave behind troublesome persister populations

Ascorbate has a varied chemistry, enabling the following functions

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The polyunsaturated nature of PUFAs enables critical signaling and membrane fluidity functions while conferring peroxidation susceptibility, rendering membranes rich in PUFA-phospholipids-synthesized by ACSL4 and LPCAT3-vulnerable to ferroptosis through iron-catalyzed Fenton reaction-mediated oxidation (116)
