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Pen injectors address this problem in several ways

You should wait at least 4 weeks between RF Microneedling treatments

You're adding a bacteriostatic agent, typically benzyl alcohol, to purified water

Cyanocobalamin Injection, USP is a sterile solution of cyanocobalamin for intramuscular or subcutaneous injection. Each mL contains 1000 mcg cyanocobalamin. Each vial also contains Sodium Chloride, 0.9%. Benzyl Alcohol, 1.5%, is present as a preservative and Water for Injection q.s. Hydrochloric acid and/or sodium hydroxidemay have been added during manufacture to adjust the pH (range 4.5-7.0)

For example, some doctors make multiple injections in small amounts between the tendons, while others may make one large injection in the center of the hand, and then direct the filler to where it needs to go once its under the skin