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They have been in the market since the 1940s and, by 2017, their global market was valued at more than USD 130 billion [79]
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Haematologica 108 (2), 353366
D5879, Merck) and frozen at 80 C overnight before being moved to liquid nitrogen
Patients were assigned to receive once-daily NAC 2 g for 4 weeks and demonstrated reduced depression symptoms, while the placebo group experienced more severe signs of depression at the end of the trial (183)
