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Description
in primary dermal fibroblasts
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This pathway is hyperactivated in NF1-related tumours, and inhibition of MAPK kinase (MEK) was effective at controlling tumour size in a mouse model of NF1
For example, inhibitors targeting histone demethylases (such as KDM5 inhibitors like CPI-455 or ryuvidine) have demonstrated efficacy in preclinical models by preventing the reversible repression of chromatin states necessary for DTP survival (Vinogradova et al., 2016
While individual results vary, most people find that consistent daily supplementation for at least a month provides the most noticeable benefits
