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Similar results were obtained using VRK2-WT and VRK2-KO cells (Fig

Iron-dependent enzymes known to drive ferroptosis include lipoxygenases (LOX), cyclooxygenases (COX), and cytochrome P450 oxidoreductases (POR) [53,54,55,56], all of which catalyse the formation of bioactive LOOH, which regulates cellular signalling
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In this pathway, the protein Ub, belongs to a family of heat shock proteins (HSPs), is covalently bound by thiol groups to misfolded or damaged proteins and contributes in their breakdown by transferring them to the protease 26S complex

This surveillance is advised until patients undergo a prophylactic hysterectomy, a definitive risk-reducing measure (21)
