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Likewise, via the CXCL12/CXCR4 axis, BMMSC advances PCa both in vivo and in vitro [209]

Kirchheiner J, Brockmoller J

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Studies examining fibroblast and endothelial cell systems show increased phosphorylation of focal adhesion kinase and paxillin, two proteins central to cytoskeletal organization and cell adhesion signaling

In addition to promote TGF- ligand production, high glucose is shown to increase cell membrane levels of both TRI and TRII and to induce latent-TGF- activation by matrix metalloproteinases, leading to activation of the Akt-mTOR pathway and consequently causing cell hypertrophy in fibroblasts and epithelial cells ( FIGURE 2 TGF- signaling also regulates other components in the glycolytic pathway (Figure 2