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In response to repetitive highfrequency steps of the stimulus, inhibition removal may be too slow, and hence, activity would not be observed in response to all repetitive stimulations, a phenomenon known as periodic skipping (compare Appendix Fig S1B and C and see also experimental evidence in Larsch et al , 2015

Yet the intense focus on results, efficiency, and cost-cutting can comparatively deprioritize an appropriate focus on developing safety management approaches and culture in portfolio companies