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Animal models have demonstrated increased ammonia levels lead to intracellular production of reactive oxygen species, induction of cellular apoptosis in bovine epithelial cells, increased inflammatory cytokines and repression of DNA repair-related genes in porcine Type II alveolar epithelial cells 48, 49

Furthermore, the activation of NRF2 was observed to confer resistance to erastin- and RSL3-induced ferroptosis in GBM cells [95] (Fig

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(2002) 4-Hydroxynonenal affects pRb/E2F pathway in HL-60 human leukemic cells, Biochem