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However, as part of the natural aging process, our bodies essentially slow down their production of this vital protein, and starting in our mid-20s, we begin to lose about one percent of collagen annually

[PMC free article: PMC3511587] [PubMed: 23143598] 385

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When to seek medical care Severe persistent vomiting, signs of pancreatitis (severe upper-abdominal pain, often radiating to the back), severe allergic reactions, or any reaction that is getting worse rather than better are reasons to stop and seek qualified medical care