glutathione s transferase crystal structure RCSB PDB X-ray crystal structures of cytosolic

PMID: 38 FridmanWHZitvogelLSautes-FridmanCKroemerG

P value from two-sided Dunnetts multiple comparisons test adjusted for multiple comparison

EJ Erica J

doi: 10.1155/2018/2469486

The entry of cisplatin into the inner ear leads to the formation of inner ear cellular damage products (DAMPs), which, together with cisplatin, bind to toll-like receptors (TLRs) (Babolmorad et al., 2021) and activate downstream signaling, producing transcription factors (e.g., nuclear factor kappa B (NF-B), activator protein-1 (AP-1), and interferon regulatory factor 3 (IRF3)), which in turn regulate the expression and secretion of proinflammatory signaling molecules