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Treatment was initiated with a prolonged prednisone taper, starting at 1 mg/kg, in conjunction with mycophenolate mofetil at a dose of 1 g daily

The 50 ppm dose level can be considered as a non-toxic-effect level in the 90-day study

Because ARE-type cis -acting sequences exist in the regulatory region of Prdx6 promoter (357/349), we envisaged that a potential loss of Prdx6 might be related to Nrf2 dysregulation in aging
