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Ferroptosis in cardiovascular diseases: current status, challenges, and future perspectives

254 Oxidative stress, such as H 2 O 2 in diabetic retinopathy, increases H3K4me3 and H3K27me3 while reducing the acetylation of histones such as H3K9ac and H4K8ac

The consequences of NNMT overexpression create a metabolic feedback loop that promotes and maintains obesity

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Albumin is the most abundant protein in plasma, with a concentration of 3050 g/L, which corresponds to 50% of all plasmatic proteins.13,25 Despite albumins plasmatic abundance, the majority of albumin is not in circulation, as 60% is stored in the interstitial space.23,28 In fact, although the half-life of albumin is about 17 days, albumin only lasts 1618 h in circulation.23,24 The transcapillary escape of albumin can be reverted, as albumin can eventually return into the plasma component via lymphatic return to maintain steady plasma concentrations.29 Albumin is predominantly synthesized in the liver, although albumin mRNA was detected in extra-hepatic localizations, such as pancreas, kidney and brain.30 Nahon, et al