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To assess the effect of liraglutide treatment and the role of cell GLP-1R signaling on cell GLP-1 expression, pancreatic sections from these mice were costained for GLP-1 and glucagon, using an antibody that has been rigorously validated to be specific for GLP-1 (29)
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Intranasal administration has also been investigated in some preclinical models

Oral cimetidine gives effective symptom relief in painful bladder disease: a prospective, randomized, double-blind placebo-controlled trial
