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Limitations such as a possible ceiling effect in patients receiving effective bosentan therapy could be responsible for the insignificant difference between the groups

Billy Dunn, director of the Office of Neuroscience in the FDAs Center for Drug Evaluation and Research
Overall Health : Comorbid conditions, such as diabetes and smoking, can significantly impair healing processes
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doi: 10.1007/s10815-006-9084-7 187 MakhlufSBAbu-MukhRRubinsteinSBreitbartHGedankenA
