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doi: 10.1126/science.aax1184 [DOI] [PMC free article] [PubMed] [Google Scholar] 11.Garcia A, Coss A, Luis-Islas J, Puron-Sierra L, Luna M, Villavicencio M, et al

Mitochondria-targeted drugs can also synergize with immune checkpoint blockade therapy by reversing tumor hypoxia, inhibiting PD-L1 expression, or inducing ICD, reversing immunosuppression TME, and reducing tumor necrosis factor- expression, enhance the effect of photodynamic immunotherapy, enhance T cell lytic activity, and then enhance tumor immunity

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However, a few subunits demonstrate regional or celltype specificity

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