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However, the lack of a clearly defined primary molecular target and the complexity of the peptide mixture present significant challenges for mechanistic understanding and clinical translation

doi: 10.1002/jcp.30582 54 FengDZouJSuDMaiHZhangSLiPet al

Because GHK-Cu stimulates the skin's own collagen-producing machinery rather than temporarily plumping the surface, the firmness improvement is structural it's still there months later, not gone the moment a filler effect wears off

In addition, they did not find specific antibodies against L