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10.1097/j.pain.0000000000002688 14 BaldoB

Mewborn AL, Kessler JM

Symptoms following acute NSAID overdose are usually limited to lethargy, drowsiness, nausea, vomiting and epigastric pain, gastrointestinal bleeding can occur but very rarely, hypertension, acute renal failure, respiratory depression and coma

These considerations exemplify a broader theme for NGPs: achieving their therapeutic potential will require integrating high-resolution hostmicrobiome science with appropriate regulatory frameworks, advanced manufacturing technologies, and precision medicine approaches that align specific NGPs or consortia with defined clinical indications and patient subgroups

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