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Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4

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[14] There is a mutant form of aldehyde dehydrogenase, termed ALDH2*2, wherein a lysine residue replaces a glutamate in the active site at position 487 of ALDH2

However, the compound faced limitations in clinical trials due to pulmonary toxicity [109]

however, formulating a topical agent has been difficult due to its instability
