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In this mouse model, the activity of the AMPK/peroxisome proliferator-activated receptor-gamma coactivator-1 pathway was increased, and activity of the f NF-B/IL-1/NLR family pyrin domain 3 signaling pathway was decreased in the hippocampus and prefrontal cortex

Curcumin has been shown to restore oxidative balance by reversing changes in malondialdehyde levels, catalase activity, and key antioxidant enzymes such as superoxide dismutase and glutathione, while also helping regulate electrolyte balance, reduce liver fibrosis, and lower biomarkers associated with liver damage, suggesting a protective role against liver cirrhosis (Zaidi and Mahboob, 2020)

Sugino T, Hasegawa Y, Kikkawa Y, Yamaura J, Yamagishi M, Kurose Y, Kojima M, Kangawa K, Terashima Y (2002) A transient ghrelin surge occurs just before feeding in a scheduled meal-fed sheep

10.1016/j.biopha.2023.114252 12 HuangD.ShenP.WangC.GaoJ.YeC.WuF

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