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We suggest that the efficiency of thiol oxidation catalyzed by SOD1 is a function of its Cu 2+ content, which in turn reflected the efficiency, with which Cu 2+ was incorporation into the tested SOD1 variants upon the reconstitution (see Methods)

Zinc and copper are also synergists and antagonists

GHK-Cu is a tripeptide consisting of three amino acids glycine, histidine, and lysine bound to a copper(II) ion

It offers anti-inflammatory and antioxidant properties

There were possibly significant increases in arginine and glycine, with both changing from slightly below the average neurotypical value to slightly above