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This rewiring is quantifiable through key metabolic indicators: elevated glutamine uptake (via transporters SLC1A5/ASCT2), increased flux through glutaminase (GLS)-dependent deamidation, accumulation of -ketoglutarate (-KG) and glutamate, and altered NADPH/NADP + ratios and glutathione (GSH) synthesis rates (65)

[DOI] [PMC free article] [PubMed] [Google Scholar] [41].Bouhrara M, Reiter DA, Bergeron CM, Zukley LM, Ferrucci L, Resnick SM, et al

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The mismatched TEC also brings about delamination of the layered structure (Fig