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Similarly, IL-1-induced BMSC-Exos reversed hemin-induced ferroptosis in neuronal cells, including high iron, ROS, malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and reduced GSH level and cell viability [143]

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The authors concluded that the APOE cell surface receptor sortilin facilitates neuroprotection which is disrupted in APOE4 carriers (Asaro et al