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Direct SlC7A11 overexpression in cardiac myocytes boosted GSH levels and reduced cardiac ferroptosis and injury, suggesting that it is feasible to fortify GSH levels by increasing SLC7A11 [76]
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10.1074/jbc.m313561200 J
doi: 10.1002/ajh.24088 25 GrayL
This work suggests a general mechanism wherein selective autophagy receptors can distinguish between the inactive pools of monomeric LC3/GABARAPs and the active oligomerized forms that drive autophagy
