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Concurrently, exercise is recognized for its ability to stimulate the release of neurotrophic factors [proteins that support the growth, survival, and differentiation of neurons, as well as promote neurogenesis, synaptic plasticity, and repair of the nervous system, playing a critical role in maintaining neural health and function], like BDNF and insulin-like growth factor 1 (IGF-1), which enhance neural connectivity and reduce the risk of cognitive decline [7]

IAA, a pathway for indole production by tryptophan metabolism in Escherichia and others, was shown to be effective in the production of indole via the AHR signaling pathway [182] in VEGF-treated human umbilical vein endothelial cells (HUVEC) exerts anti-angiogenic effects and is able to inhibit VEGF receptor-2 and eNOS phosphorylation in HUVEC cultures with reduced NO production and decreased vasodilatory capacity [183]

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The methods used for the supplemental figures are described in the Supplemental Methods

Gastrointestinal Research Highlights Intestinal permeability: BPC-157 has been shown to stabilize intestinal permeability and enhance cytoprotective mechanisms, rescuing NSAID-induced cytotoxicity in preclinical models (Park et al., 2020, Curr Pharm Des )