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In high-altitude cerebral edema (HACE) which is characterized by inflammation and hypoxia, proteins in the nucleosome remodeling and histone deacetylase (NuRD) complex of microglial is lactylated, which upregulates the expression of various pro-inflammatory factors in M1-type microglia and enhances NF-B pathway activity, thereby exacerbating LPS-induced neuroinflammatory conditions [133]

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Cook L.J., Davies J., Yates A.P., Elliott A.C., Lovell J., Joule J.A., Pemberton P., Thornalley P.J., Best L

IGF-1 promotes breast carcinoma cell migration through the formation of lamellipodia and focal adhesions [108,113,114]

Nonconventional Treatment 4.2.1

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