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However, upon starvation, MXL-3/MAX is downregulated and allows HLH-30/TFEB to access the promoter region and thus upregulates expression of the lipases that are necessary for the lysosomal breakdown of lipids, ensuring survival during starvation conditions [31, 36]

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The internet may have splintered the pop monoculture into myriad musical streams, but Heady Fwends provides as inclusive a congregation of the entire, circa-2012 under-to-overground spectrum as you can muster in a single album, with a guest list that spans top-40 stars (Ke$ha, Chris Martin) and noise-rock extremists (Lightning Bolt), anarchic avant guardians (Nick Cave, Yoko Ono) and chilled-out indie new-schoolers (Bon Iver, Neon Indian), electronic experimentalists (Prefuse 73) and hip-hop heroes-cum-children's-television hosts (Biz Markie)