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In monkeys, it increased blood flow and oxygen consumption through the brain [149]

[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Dean O., Giorlando F., Berk M

Targeting the hypoxic microenvironment by mTOR inhibitors sensitizes ALL cells to chemotherapy

doi: 10.1007/s00216-010-3874-6

thus, researchers are trying to increase the tumor permeability by replacing antibodies with smaller peptides and aptamers [143, 207]
