what is melanotic macules macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Relative frequency of solitary melanocytic
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Significant differences were observed in the proportion of stage III melanosomes ( p = 2.575e-7, effect size r = 0.8358) and stage II melanosomes ( p = 1.568e-8, effect size r = -0.9054)
6,7 They can occur at any age, though the median onset is between 55 and 60 years old and only 1% of cases occur in people under 20
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