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For example, study reported that long-term treatment with low doses of caffeine exacerbated neuropsychiatric symptoms, called behavioral and psychological symptoms of dementia in 3xTg-AD mice models of AD (Baeta-Corral et al., 2018)

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Expanded ataxin-3 in SCA3 perturbs cellular signaling by hyperactivating the ERK branch of the MAPK cascade while inhibiting pro-apoptotic pathways, producing an imbalanced survival-death response that accelerates neurodegeneration 96

NFB inhibition protected mice from severe water loss and diarrhea, which indicated its role in the regulation of the barrier property of IECs

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