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In the duodenum, pancreatic enzymes degrade haptocorrin, allowing B12 to bind to intrinsic factor

[DOI] [PubMed] [Google Scholar] 26.Xu Z.N., Lin Z.Q., Zhao G.S., Guo Y.B

They can be unsafe for humans, unsafe in the amounts youre taking, or unsafe for you even if your friend got great results, he says

Typical conversions from animal studies use body-surface-area scaling: Rat dose: 10 g/kg human equivalent ( 0.162) 1.6 g/kg For a 70 kg adult: ~112 g per day Self-experiment protocols often cite 100200 g once or twice daily via subcutaneous injection

Always use bacteriostatic water , not sterile water, for reconstitution when you plan to draw multiple doses from the vial over several weeks