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In particular, the PPAR pathway, as a molecular switch of lipid metabolism, is crucial in the regulation of lipid metabolism, energy balance and insulin sensitivity (48)

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Hypertension (20 [50%]) was the most common risk factor followed by tobacco use (12 [30%]), CAD (10 [25%]), diabetes mellitus (10 [25%]), dyslipidemia (8 [20%]), prior stroke (7 [17.5%]), alcohol abuse (6 [15%]), non valvular atrial fibrillation (NVAF) (6 [15%]), RHD (2 [5%]) and CKD (2 [5%]) (Table 2)