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Other candidates include IO-108, which has shown promise in activating cytotoxic T lymphocytes and APCs, and ES009, which is being evaluated for its safety and ability to potentiate T cell activation (93)

But the addition of glucagon receptor agonism overwhelms the GIP benefit

It encourages the differentiation of macrophages into pro-fibrotic M2 phenotypes and an increase in extracellular matrix synthesis, which exacerbates renal fibrosis

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