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To view a copy of this license, visit About this article Cite this article Zhang, W., Gong, M., Zhang, W

No large, placebo-controlled, randomized trials have been completed
Zhou Y, Teng X, Han M, Shi J, Li C, Zhang X, et al

Concurrently, mitochondrial ROS (mtROS) amplifies vascular dysfunction by oxidizing BH4, uncoupling endothelial eNOS, and reducing NO bioavailability while also activating pro-inflammatory pathways (e.g., NLRP3 inflammasome) and stimulating NOX activity, creating continuous oxidative damage (Penna and Pagliaro, 2025)

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