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Description
PD involves the progressive degeneration of dopamine-producing neurons in the substantia nigra, resulting in reduced dopamine neurotransmitter in the striatum as shown in Fig

Minchenko A, Leshchinsky I, Opentanova I, Sang N, Srinivas V, Armstead V, Caro J

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Complexity of mitochondrial diseases causing neurodevelopmental disorders, lack of profitability of industry derived from the low frequency of these diseases and the difficulty that still exists in developing brain organoids reproducible, reliable and scalable are some of the limitations

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