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This supports the view that ox-mtDNA acts as a mobile spark for aging-related multi-organ inflammation (Victorelli et al., 2023)

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Menthol also helps inhibit sodium ion channels, which are responsible for transmitting chronic pain signals, while providing anti-inflammatory benefits by reducing local inflammatory responses

It is therefore plausible that metabolic alterations and/or oxidative and nitrosative stress in ME/CFS lead to glial dysfunction (Cobb and Cole, 2015

[] Low hemoglobin levels may contribute to reduced physical activity, intensified fatigue, a lack of appetite, and a worse quality of life, hence increasing the possibility of hospitalization